3l0k | pdb_00003l0k

Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP

spinqualitylabelsall models 3l0k, resolution 1.34Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 3l0k is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3ex0. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.34Å Ligands: 6AU, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease UMPS_HUMAN Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:258900. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies. Function UMPS_HUMAN Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Phosphoribosyltransferase 3D structures Uridine 5'-monophosphate synthase 3D structures

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