1tou | pdb_00001tou
Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand
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Overview
The synthesis and biological evaluation of novel human A-FABP inhibitors, based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is, described. Two series of compounds, bearing either an amino or carbon, substituent in the 2-position of the pyrimidine ring were investigated., Modification of substituents and chain length optimization led to novel, compounds with low micromolar activity and good selectivity for human, A-FABP.
About this Structure
1TOU is a Single protein structure of sequence from Homo sapiens with B1V as ligand. Full crystallographic information is available from OCA.
Reference
Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970
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