5hy3 | pdb_00005hy3

Crystal structure of Escherichia coli toxin LsoA in complex with T4 phage antitoxin Dmd

spinqualitylabelsall models 5hy3, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 5hy3 is a 2 chain structure with sequence from Escherichia coli O157:H7 and Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.1Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function LSOA_ECO57 Toxic component of a toxin-antitoxin (TA) module. A stable (half-life over 20 minutes) endoribonuclease that degrades mRNA. Degradation may be translation-stimulated. Overexpression in the absence of cognate antitoxin LsoB causes retarded growth and mRNA degradation, this effect is mitigated upon coexpression with antitoxin LsoB or enterobacteria phage T4 Dmd. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction.

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