| Structural highlights
8u87 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
| | Method: | Electron Microscopy, Resolution 3.86Å |
| Ligands: | D12, FAD, HEB, NDP, ZN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
NOX5_HUMAN Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.[1] [2] [3]
References
- ↑ Banfi B, Molnar G, Maturana A, Steger K, Hegedus B, Demaurex N, Krause KH. A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem. 2001 Oct 5;276(40):37594-601. doi: 10.1074/jbc.M103034200. Epub 2001, Aug 1. PMID:11483596 doi:https://dx.doi.org/10.1074/jbc.M103034200
- ↑ Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD, Hoidal JR. NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69. doi:, 10.1152/ajpcell.00525.2002. Epub 2003 Apr 9. PMID:12686516 doi:https://dx.doi.org/10.1152/ajpcell.00525.2002
- ↑ BelAiba RS, Djordjevic T, Petry A, Diemer K, Bonello S, Banfi B, Hess J, Pogrebniak A, Bickel C, Gorlach A. NOX5 variants are functionally active in endothelial cells. Free Radic Biol Med. 2007 Feb 15;42(4):446-59. Epub 2006 Nov 3. PMID:17275676 doi:https://dx.doi.org/S0891-5849(06)00701-5
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