XIP1_WHEAT Fungal xylanase inhibitor. Possesses competitive inhibiting activity against fungal endo-1,4-beta-D-xylanases belonging to glycoside hydrolase family 10 (GH10) and family 11 (GH11). Possesses also inhibitory activity towards barley alpha-amylases. Binding to xylanases or amylases is necessary for inhibition activity. May function in plant defense against secreted fungal pathogen xylanases. Is similar to class III chitinases, but does not exhibit chitinase activity.[1][2][3][4]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
↑Elliott GO, Hughes RK, Juge N, Kroon PA, Williamson G. Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor. FEBS Lett. 2002 May 22;519(1-3):66-70. PMID:12023019
↑McLauchlan WR, Garcia-Conesa MT, Williamson G, Roza M, Ravestein P, Maat J. A novel class of protein from wheat which inhibits xylanases. Biochem J. 1999 Mar 1;338 ( Pt 2):441-6. PMID:10024521
↑Flatman R, McLauchlan WR, Juge N, Furniss C, Berrin JG, Hughes RK, Manzanares P, Ladbury JE, O'Brien R, Williamson G. Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat. Biochem J. 2002 Aug 1;365(Pt 3):773-81. PMID:11955286 doi:https://dx.doi.org/10.1042/BJ20020168
↑Sancho AI, Faulds CB, Svensson B, Bartolome B, Williamson G, Juge N. Cross-inhibitory activity of cereal protein inhibitors against alpha-amylases and xylanases. Biochim Biophys Acta. 2003 Aug 21;1650(1-2):136-44. PMID:12922177
