4a0e | pdb_00004a0e

Crystal structure of the cytoplasmic N-terminal domain of Yersinia pestis YscD

spinqualitylabelsall models 4a0e, resolution 2.04Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4a0e is a 2 chain structure with sequence from Yersinia pestis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.042Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q56975_YERPE Publication Abstract from PubMed The Yersinia pestis YscD protein is an essential component of the type III secretion system. YscD consists of an N-terminal cytoplasmic domain (residues 1-121), a transmembrane linker (122-142) and a large periplasmic domain (143-419). Both the cytoplasmic and the periplasmic domains are required for the assembly of the type III secretion system. Here, the structure of the YscD cytoplasmic domain solved by SAD phasing is presented. Although the three-dimensional structure is similar to those of forkhead-associated (FHA) domains, comparison with the structures of canonical FHA domains revealed that the cytoplasmic domain of YscD lacks the conserved residues that are required for binding phosphothreonine and is therefore unlikely to function as a true FHA domain. Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system.,Lountos GT, Tropea JE, Waugh DS Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):201-9. Epub 2012 Feb 7. PMID:22349221 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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