2m64 | pdb_00002m64

1H, 13C and 15N Chemical Shift Assignments for Phl p 5a

spinqualitylabelsall models 2m64 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2m64 is a 1 chain structure with sequence from Phleum pratense. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MPAP5_PHLPR Publication Abstract from PubMed This is the first study determining the three-dimensional structure of Phl p 5a which reveals a novel mechanism for high allergenic activity based on flexibly connected IgE-reactive domains which cross-link effector cell-bound IgE more efficiently than isolated rigid globular proteins. These findings may also form a basis for specific immunotherapy strategies. Flexible IgE epitope-containing domains of Phl p 5 cause high allergenic activity.,Gobl C, Focke-Tejkl M, Najafi N, Schrank E, Madl T, Kosol S, Madritsch C, Dorofeeva Y, Flicker S, Thalhamer J, Valenta R, Zangger K, Tjandra N J Allergy Clin Immunol. 2017 Oct;140(4):1187-1191. doi: , 10.1016/j.jaci.2017.05.005. Epub 2017 May 19. PMID:28532654 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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