Structural highlights
Function
TKN4_HUMAN Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin-C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility.[1] [2] [3] [4]
References
- ↑ Page NM, Bell NJ, Gardiner SM, Manyonda IT, Brayley KJ, Strange PG, Lowry PJ. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6245-50. Epub 2003 Apr 25. PMID:12716968 doi:https://dx.doi.org/10.1073/pnas.0931458100
- ↑ Yoshioka D, Takebuchi F, Nishimori T, Naono R, Ikeda T, Nakayama T. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci Lett. 2006 Dec 27;410(3):193-7. Epub 2006 Nov 13. PMID:17101218 doi:https://dx.doi.org/10.1016/j.neulet.2006.09.024
- ↑ Ravina CG, Seda M, Pinto FM, Orea A, Fernandez-Sanchez M, Pintado CO, Candenas ML. A role for tachykinins in the regulation of human sperm motility. Hum Reprod. 2007 Jun;22(6):1617-25. Epub 2007 Apr 16. PMID:17437961 doi:https://dx.doi.org/dem069
- ↑ Naono R, Nakayama T, Ikeda T, Matsushima O, Nishimori T. Leucine at the carboxyl-terminal of endokinins C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007 Aug 24;1165:71-80. Epub 2007 Jul 3. PMID:17655832 doi:https://dx.doi.org/S0006-8993(07)01265-6
