A Disintegrin And Metalloproteinase

spinqualitylabelsall models A Disintegrin And Metalloproteinase complex with sulfate 2ao7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered. ADAM10 cleaves ephrin. ADAM13 details are in Molecular Playground/ADAM13. ADAM17 (TACE or TNF-α converting enzyme) processes the tumor necrosis factor-α. ADAM33 is implicated in asthma. ADAMTS is ADAM with thrombospondin motifs. ADAMTS1 has anti-angionenic activity. ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan. ADAMTS13 cleaves Von Willebrand Factor involved in blood clotting. Disease ADAM inhibitors are used in anti-cancer therapy. ADAM10 is a therapeutic target for cancer and inflammation . ADAM17 is a therapeutic target for multiple diseases .ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting. ADAM33 is a therapeutic target for asthma . 3D Structures of A Disintegrin And Metalloproteinase A Disintegrin And Metalloproteinase 3D structures

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