6ykp | pdb_00006ykp

Structure of unplugged C. jejuni MotAB

spinqualitylabelsall models 6ykp, resolution 2.98Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ykp is a 7 chain structure with sequence from Campylobacter jejuni subsp. jejuni 81-176. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.98Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0H3PAV1_CAMJJ Publication Abstract from PubMed Many bacteria use the flagellum for locomotion and chemotaxis. Its bidirectional rotation is driven by a membrane-embedded motor, which uses energy from the transmembrane ion gradient to generate torque at the interface between stator units and rotor. The structural organization of the stator unit (MotAB), its conformational changes upon ion transport, and how these changes power rotation of the flagellum remain unknown. Here, we present ~3 A-resolution cryoelectron microscopy reconstructions of the stator unit in different functional states. We show that the stator unit consists of a dimer of MotB surrounded by a pentamer of MotA. Combining structural data with mutagenesis and functional studies, we identify key residues involved in torque generation and present a detailed mechanistic model for motor function and switching of rotational direction. Structure and Function of Stator Units of the Bacterial Flagellar Motor.,Santiveri M, Roa-Eguiara A, Kuhne C, Wadhwa N, Hu H, Berg HC, Erhardt M, Taylor NMI Cell. 2020 Sep 7. pii: S0092-8674(20)31007-2. doi: 10.1016/j.cell.2020.08.016. PMID:32931735 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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