7m7a | pdb_00007m7a

Legionella pneumophila MavQ lipid kinase

spinqualitylabelsall models 7m7a, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7m7a is a 4 chain structure with sequence from Legionella pneumophila. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: ADP, MG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5ZRA8_LEGPH Publication Abstract from PubMed During infection Legionella bacteria translocate a variety of effectors into host cells that modify host cell membrane trafficking for the benefit of the intracellular pathogen. Here we found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The Legionella effector MavQ, a phosphatidylinositol (PI) 3-kinase, was targeted to the endoplasmic reticulum (ER). MavQ and the Legionella PI 3-phosphatase SidP, even in the absence of other bacterial components, drove rapid PI 3-phosphate turnover on the ER, spontaneously forming traveling waves that spread along ER subdomains inducing vesicle/tubule budding. Thus, bacteria can exploit a self-organizing membrane-targeting mechanism to hijack host cellular structures for survival. Dynamic remodeling of host membranes by self-organizing bacterial effectors.,Hsieh TS, Lopez VA, Black MH, Osinski A, Pawlowski K, Tomchick DR, Liou J, Tagliabracci VS Science. 2021 Apr 29. pii: science.aay8118. doi: 10.1126/science.aay8118. PMID:33927055 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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