Arrestin

spinqualitylabelsall models Bovine arrestin-2 complex with Ba+2 ions (PDB code 2wtr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Arrestin (ARR) is a ubiquitous protein which binds to the G protein-coupled receptor after its phosphorylation. ARR binding blocks further G protein-mediated signaling and redirects signaling to alternative non-G protein-independent pathways. Hence, ARR are versatile adaptor molecules which can also activate signaling cascades and are involved in nuclear functions. Arrestin-2 is regulator of B-cell function. Arrestin-3 assists in activation of JNK3 . Arrestin-4 or cone arrestin binds in a cone cell th G protein kinase to desensitise opsin. S-arrestin binds to photo activated Rho and terminates its signaling. Structural highlights ARR consist of 2 domains. The N terminal domain structure is immunoglobulin-like. The binding site of phosphorylated light-activated rhodopsin is located at the N terminal of ARR. Ba+2 ion binding sites. 3D Structures of arrestin Arrestin 3D structures

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky