2j0d | pdb_00002j0d
CRYSTAL STRUCTURE OF HUMAN P450 3A4 IN COMPLEX WITH ERYTHROMYCIN
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Overview
Cytochrome P450 (CYP) 3A4 is the most promiscuous of the human CYP enzymes, and contributes to the metabolism of approximately 50% of marketed drugs., It is also the isoform most often involved in unwanted drug-drug, interactions. A better understanding of the molecular mechanisms governing, CYP3A4-ligand interaction therefore would be of great importance to any, drug discovery effort. Here, we present crystal structures of human CYP3A4, in complex with two well characterized drugs: ketoconazole and, erythromycin. In contrast to previous reports, the protein undergoes, dramatic conformational changes upon ligand binding with an increase in, the active site volume by >80%. The structures represent two distinct open, conformations of CYP3A4 because ketoconazole and erythromycin induce, ... [(full description)]
About this Structure
2J0D is a [Single protein] structure of sequence from [Homo sapiens] with ERY and HEM as [ligands]. The following page contains interesting information on the relation of 2J0D with [Cytochrome p450]. Full crystallographic information is available from [OCA].
Reference
Structural basis for ligand promiscuity in cytochrome P450 3A4., Ekroos M, Sjogren T, Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13682-7. Epub 2006 Sep 5. PMID:16954191
Page seeded by OCA on Mon Oct 29 18:34:21 2007
