Structural highlights
8yr2 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | Electron Microscopy, Resolution 2.89Å |
| Ligands: | 41U, A1LX7, CL, CLR, NA, PIO |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Disease
SC6A2_HUMAN Postural orthostatic tachycardia syndrome due to NET deficiency. The disease is caused by variants affecting the gene represented in this entry.
Function
SC6A2_HUMAN Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921). Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:11093780, PubMed:8125921).[1] [2] [3]
References
- ↑ Syringas M, Janin F, Mezghanni S, Giros B, Costentin J, Bonnet JJ. Structural domains of chimeric dopamine-noradrenaline human transporters involved Mol Pharmacol. 2000 Dec;58(6):1404-11. PMID:11093780 doi:10.1124/mol.58.6.1404
- ↑ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine transporter. Nature. 1991 Mar 28;350(6316):350-4. PMID:2008212 doi:10.1038/350350a0
- ↑ Gu H, Wall SC, Rudnick G. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J Biol Chem. 1994 Mar 11;269(10):7124-30 PMID:8125921
