8xcj | pdb_00008xcj

Open State of central tail fiber of bacteriophage lambda upon binding to LamB (gpJ713-LamB complex)

spinqualitylabelsall models 8xcj, resolution 2.98Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8xcj is a 6 chain structure with sequence from Escherichia phage Lambda and Shigella sonnei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.98Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0I1R9L6_SHISO Involved in the transport of maltose and maltodextrins.[HAMAP-Rule:MF_01301] Publication Abstract from PubMed Bacteriophage infection, a pivotal process in microbiology, initiates with the phage's tail recognizing and binding to the bacterial cell surface, which then mediates the injection of viral DNA. Although comprehensive studies on the interaction between bacteriophage lambda and its outer membrane receptor, LamB, have provided rich information about the system's biochemical properties, the precise molecular mechanism remains undetermined. This study revealed the high-resolution cryo-electron microscopy (cryo-EM) structures of the bacteriophage lambda tail complexed with its irreversible Shigella sonnei 3070 LamB receptor and the closed central tail fiber. These structures reveal the complex processes that trigger infection and demonstrate a substantial conformational change in the phage lambda tail tip upon LamB binding. Providing detailed structures of bacteriophage lambda infection initiation, this study contributes to the expanding knowledge of lambda-bacterial interaction, which holds significance in the fields of microbiology and therapeutic development. Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor.,Ge X, Wang J Nat Commun. 2024 May 17;15(1):4185. doi: 10.1038/s41467-024-48686-3. PMID:38760367 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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