8szb | pdb_00008szb

Cryo-EM Structure of NINJ2 Filament at 3.07 Angstrom Resolution

spinqualitylabelsall models 8szb, resolution 3.07Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8szb is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.07Å Ligands: CLR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function NINJ2_HUMAN Effector of necroptotic and pyroptotic programmed cell death that mediates plasma membrane rupture (cytolysis) (By similarity). Acts downstream of Gasdermin (GSDMA, GSDMB, GSDMC, GSDMD, or GSDME) or MLKL during pyroptosis or necroptosis, respectively: oligomerizes in response to death stimuli and promotes plasma membrane rupture by introducing hydrophilic faces of 2 alpha helices into the hydrophobic membrane, leading to release intracellular molecules named damage-associated molecular patterns (DAMPs) that propagate the inflammatory response (By similarity). Also acts as a homophilic transmembrane adhesion molecule involved in nerve regeneration (PubMed:10627596). Promotes axonal growth (PubMed:10627596).[UniProtKB:Q92982]

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