Function
Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules[1]. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1.
- Fiicolin-1 or M-ficolin is a pattern recognition molecule of the complement system expressed in myeloid cells[2].
Disease
Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy[3].
Structural highlights
Human H-ficolin binding domain trimer.
Ca coordination site (PDB code 2j64).[4] Water molecules shown as red spheres.
- ↑ Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:https://dx.doi.org/10.1016/S0171-2985(98)80026-0
- ↑ Honoré C, Rørvig S, Munthe-Fog L, Hummelshøj T, Madsen HO, Borregaard N, Garred P. The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. Mol Immunol. 2008 May;45(10):2782-9. PMID:18343499 doi:10.1016/j.molimm.2008.02.005
- ↑ Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118
- ↑ Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869
