Nitroreductase

spinqualitylabelsall models E. coli nitroreductase dimer containing FMN and nicotinic acid (PDB entry 1icr) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Nitroreductase or oxygen-insensitive NAD(P)H nitroreductase (NR) is involved in the reduction of nitrogen-containing compounds including those containing NO2 group. The NO2 group is reduced to hydroxylamine. NR uses FMN as cofactor. Among NRs are the oxygen-insensitive NAD(P)H NR and NADH dehydrogenase. Copper-induced nitroreductase protects Lactococcus lactis against oxidative stress exerted by nitroaromatic compounds and copper. Nitrobenzoate nitroreductase metabolises 2-nitrobenzoate to form the antioxidant 3-hydroxyanthranilate in Pseudomonas fluorescens. Deazaflavin-dependent nitroreductase catalyses the reduction of nitroimidazoles into reactive nitrogen species in Mycobacterium tuberculosis . Relevance NR is of special interest due to its potential use as activator of prodrugs in cancer therapy. Structural highlights NR cofactor FMN is bound directly to one subunit while the ligand - nicotinic acid - interacts with both subunits. Water molecules are shown as red spheres. 3D structures of nitroreductase Nitroreductase 3D structures

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