Structural highlights
8qch is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.442Å |
| Ligands: | EIF, NA, PEG, SO4, ZN |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
ADAL_HUMAN Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine (PubMed:21755941, PubMed:29884623). Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A) (PubMed:21755941, PubMed:29884623). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941).[1] [2]
References
- ↑ Murakami E, Bao H, Mosley RT, Du J, Sofia MJ, Furman PA. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate J Med Chem. 2011 Aug 25;54(16):5902-14. PMID:21755941 doi:10.1021/jm200650j
- ↑ Chen M, Urs MJ, Sánchez-González I, Olayioye MA, Herde M, Witte CP. m(6)A RNA Degradation Products Are Catabolized by an Evolutionarily Conserved N(6)-Methyl-AMP Deaminase in Plant and Mammalian Cells. Plant Cell. 2018 Jul;30(7):1511-1522. PMID:29884623 doi:10.1105/tpc.18.00236
