Rac

spinqualitylabelsall models Human Rac1 (magenta) complex with YpkA (cyan), GDP and Mg+2 ion (green) (PDB code 2h7v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function The small G-protein Rac or Ras-related C3 botulinum toxin substrate. Rac1 is involved in the regulation of cytoskeletal organization, cell adhesion, migration and morphological changes. Rac2 is expressed in hematopoietic cells exclusively. Rac3 binds to a variety of effector proteins to regulate cellular responses like cell spreading and the formation of actin-based protrusions. Disease Mutations in Rac2 are associated with neutrophil immunodeficiency syndrome. Structural highlights The interactions between Rac1 and YpkA are via switch I and switch II of Rac1 and a helical portion of the protein kinase YpkA. GDP binding site on Rac1. 3D structures of Rac Rac 3D structures

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