Syntaxin

spinqualitylabelsall models Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs. Stx-1A regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters. Stx-6 is a SNARE protein involved in a variety of internal membrane fusion events. Stx-7 is involved in endosomal membrane fusion. Stx-10 is a SNARE protein localised to the trans-Golgi network. Stx-12 is a SNARE protein localised to the endosome. Stx-13 has a role in membrane expansion during neuronal development . Stx-17 is required for autophagosome-lysosome fusion. Stx-VAM3P is involved invacuolar assembly. Relevance The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor. Structural highlights Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif (PDB code 3hd7). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions. The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives (PDB code 3ipd). 3D structures of syntaxin Syntaxin 3D structures

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Michal Harel, Alexander Berchansky