Acetylcholine binding protein 3D structures

3D Structures of Acetylcholine binding protein

Updated on 03-September-2024

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• AChBP or soluble acetylcholine receptor - Apo proteins
  • 2byn, 2y7y - Aplysia californica (AcAChBP)
    
  • 2xz6, 3sh1, 3sio, 3t4m, 5oad – AcAChBP (mutant)
    
  • 1ux2, 1i9b - Lymnaea stagnalis (LsAChBP)
    
  • 2bj0 - Bulinus truncatus
    
  • 4aod, 4aoe – AchBP – Cryo EM – Biomphalaria glabrata
    
• AChBP + marine biotoxins
  • 2wzy - AcAChBP + 13-desmethyl spirolide C
    
  • 2x00 - AcAChBP + gymnodimine A
    
• AChBP + partial agonists; Activate the receptor with partial efficacy
  • 2wn9 - AcAChBP + 4-OH-DMXBA
    
  • 2wnc - AcAChBP + tropisetron
    
  • 5oaj – AcAChBP (mutant) + tropisetron
    
  • 5lxb – AcAChBP (mutant) + palonosetron
    
  • 2yme – AcAChBP (mutant) + granisetron
    
  • 2wnj - AcAChBP + DMXBA
    
  • 2wnl - AcAChBP + anabaseine
    
  • 3u8j, 3u8k, 3u8l, 3u8m, 3u8n – LsAChBP + agonist
    
• AChBP+ions; Mimicking the ion conductance of the receptor
  • 3gua - AcAChBP + sulfate
    
• AChBP+ neonicotinoids; Insecticides with lower affinity to mammals
  • 3c79 - AcAChBP + imidacloprid
    
  • 2zju, 3wtl, 3wtn - LsAChBP + imidacloprid derivative
    
  • 3wth, 3wtm, 3wto - Ls AChBP (mutant) + imidacloprid derivative
    
  • 3c84 - AcAChBP + thiacloprid
    
  • 3wtj – LsAChBP + thiacloprid
    
  • 3wtk – LsAChBP (mutant) + thiacloprid
    
  • 2zjv - LsAChBP+clothianidin
    
  • 3wti - Ls AChBP (mutant) + clothianidin
    
  • 7dji - LsAChBP + insecticide
    
  • 7pd6, 7pdb, 7pdr, 7pe5, 7pe6 - LsAChBP (mutant) + insecticide
    
• AChBP+ non-competitive inhibitors which bind at site different than the active site and reduce the rate of receptor reaction
  • 2pjz - AcAChBP+cocaine
    
  • 2ph9 - AcAChBP+galanthamine
    
  • 2w8f, 2w8g - AcAChBP + in silico compounds
    
  • 4alx, 4bfq, 8q1m, 8qtl, 8qx2 – AcAChBP + antagonist
    
  • 5o8t, 2xys, 5obg – AcAChBP + strychnine
    
  • 5oa0, 5oal – AcAChBP (mutant) + strychnine
    
• AChBP+ peptide inhibitors
  • 2c9t, 2byp, 2br8, 5xgl, 4ez1, 5co5, 5jme - AcAChBP + conotoxin
    
  • 2uz6 – AcAChBP fragment + α-conotoxin
    
  • 1yi5 - AcAChBP+cobratoxin
    
  • 7n0w, 7n0y, 7n43, 7txf - LsAchBP + conotoxin
    
• AChBP+ nicotinic agonists enhance the action of the nAChR
  • 2pgz - AcAChBP+cocaine
    
  • 2byr - AcAChBP+methyllycaconitine
    
  • 2bys - AcAChBP+lobeline
    
  • 2xnt, 2xnu, 2xnv - AcAChBP + ligand
    
  • 3peo - AcAChBP+metocurine
    
  • 3pmz, 2xyt - AcAChBP+tubocurarine
    
  • 2byq - AcAChBP+epibatidine
    
  • 6qqp, 6qqo, 6qkk – AcAChBP + epibatidine derivative
    
• AChBP+ ligand homologs of the ligand acetylcholine
  • 3wip - LsAChBP+ acetylcholine
    
  • 1uv6 - LsAChBP+ carbamylcholine
    
  • 3zdg, 3zdh - LsAChBP+ carbamylcholine analog
    
  • 1uw6 - LsAChBP+nicotine
    
  • 5bp0 - LsAChBP+ nicotine derivative
    
  • 5o87 - AcAChBP+nicotine
    
  • 4aft - AcAChBP+nicotine analog
    
  • 4bqt - AcAChBP+ cytisine
    
  • 6t9r – AcAChBP + cytisine derivative
    
  • 5syo – AcAChBP/hAChR + cytisine
    
  • 2xz5 - AcAChBP (mutant) + acetylcholine
• AChBP+ modulator
  • 4nzb - LsAChBP+ NS9283
    
• AChBP+others
  • 2br7 - AcAChBP+ HEPES
    
  • 2y54, 2y56, 2y57, 2y58, 4zjs, 5ke4, 5kzu, 4wv9, 5bw2, 5brx – AcAChBP + azabicyclo derivative
    
  • 5tvh, 5tsf – AcAChBP + aminopyrimidine derivative
    
  • 4frr, 5tvc, 4zk4 - AcAChBP+ pyridine derivative
    
  • 5oan – AcAChBP (mutant) + glycine
    
  • 4xk9, 4xhe - AcAChBP+ pinnatoxin
    
  • 5ain - AcAChBP+ varenicline
    
  • 5obh – AcAChBP + bicuculline
    
  • 4dbm – AcAChBP + triazole
    
  • 2ymd – AcAChBP (mutant) + serotonin
    
  • 4qaa, 4qab, 4qac, 5j5f, 5j5g, 5j5h, 5j5i - LsAChBP+ aminopyrimidine derivative
    
  • 4um1 - LsAChBP+diazepane derivative
    
  • 4zjt, 4zk1 - LsAChBP+ anabaseine derivative
    
  • 4zr6, 4zru, 5y2e, 8p22 - LsAChBP+ pyridine derivative
    
  • 8p11, 8p1e, 8p1f - LsAChBP+ piperidine derivative
    
  • 5t90 – LsAChBP + LSIA
    
  • 7ndp, 7ndv – LsAChBP + biosensor
    
  • 8q1t – LsAChBP + phenanthroline
    
  • 5t90 – LsAChBP + LSIA
    
  • 7ndp, 7ndv – LsAChBP + biosensor
    
• AChBP α-7
  • 3sq6, 3sq9 – AchBP h/Ls chimera
    
  • 4hqp - AchBP h/Ls chimera + bungrotoxin
    
  • 5afh, 5afj, 5afk, 5afl, 5afm, 5afn - AchBP h/Ls chimera + lobeline
    

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Michal Harel, Jaime Prilusky