8wdq | pdb_00008wdq

Crystal Structure of Pseudomonas aeruginosa SuhB in complex with D-myo-inositol-1-phosphate

spinqualitylabelsall models 8wdq, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8wdq is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.2Å Ligands: ACT, CA, CL, DTU, GOL, IPD, PEO Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SUHB_PSEAE Part of the processive rRNA transcription and antitermination complex (rrnTAC). The complex forms an RNA-chaperone ring around the RNA exit tunnel of RNA polymerase (RNAP). It supports rapid transcription and antitermination of rRNA operons, cotranscriptional rRNA folding, and annealing of distal rRNA regions to allow correct ribosome biogenesis. This subunit may play a central role in organizing the structure.[UniProtKB:P0ADG4] A ribosome-associated protein, deletion of which alters the expression of 494 genes, suggesting a role in global gene regulation (PubMed:26179141). Involved in control of pathogenesis-related genes. Required for the activation of virulence factors associated with acute infections (type 3 secretion system, T3SS) while suppressing virulence factors associated with chronic infections (biofilm formation and type 6 secretion system, T6SS). It probably acts at a post-transcriptional level (PubMed:24169572).

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