8uxq | pdb_00008uxq

Structure of Heterochromatin Protein 1 (HP1) alpha in complex with an H2A.Z nucleosome

spinqualitylabelsall models 8uxq, resolution 6.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8uxq is a 12 chain structure with sequence from Homo sapiens, Mus musculus, Xenopus laevis and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 6.3Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CBX5_HUMAN Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

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