9gmo | pdb_00009gmo

eIF6-bound pre-60S large ribosomal subunit incorporating mutant uL16

spinqualitylabelsall models 9gmo, resolution 2.59Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9gmo is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.59Å Ligands: 1MA, 5MC, 6MZ, A2M, EPE, GTP, K, MG, NA, OMC, OMG, OMU, PSU, UR3, UY1, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function RL8_HUMAN Publication Abstract from PubMed Eukaryotic ribosome assembly is an intricate process that involves four ribosomal RNAs, 80 ribosomal proteins, and over 200 biogenesis factors that take part in numerous interdependent steps. This complexity creates a large genetic space in which pathogenic mutations can occur. Dead-end ribosome intermediates that result from biogenesis errors are rapidly degraded, affirming the existence of quality control pathway(s) that monitor ribosome assembly. However, the factors that differentiate between on-path and dead-end intermediates are unknown. We engineered a system to perturb ribosome assembly in human cells and discovered that faulty ribosomes are degraded via the ubiquitin proteasome system. We identified ZNF574 as a key component of a novel quality control pathway, which we term the Ribosome Assembly Surveillance Pathway (RASP). Loss of ZNF574 results in the accumulation of faulty biogenesis intermediates that interfere with global ribosome production, further emphasizing the role of RASP in protein homeostasis and cellular health. ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates.,Akers J, Bothe A, Suh H, Jung C, Stolp Z, Ghosh T, Yan L, Wang Y, Grismer T, Reyes A, Hu T, Xu S, Ban N, Kostova K bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591394. doi: , 10.1101/2024.04.26.591394. PMID:38746087 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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