9b0l | pdb_00009b0l

Cryo-EM structure of Acanthamoeba polyphaga mimivirus Fanzor2 ternary complex

spinqualitylabelsall models 9b0l, resolution 2.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9b0l is a 5 chain structure with sequence from Acanthamoeba polyphaga mimivirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.99Å Ligands: MG, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function YL079_MIMIV Publication Abstract from PubMed RNA-guided endonucleases, once thought to be exclusive to prokaryotes, have been recently identified in eukaryotes and are called Fanzors. They are classified into two clades, Fanzor1 and Fanzor2. Here we present the cryo-electron microscopy structure of Acanthamoeba polyphaga mimivirus Fanzor2, revealing its omegaRNA architecture, active site and features involved in transposon-adjacent motif recognition. A comparison to Fanzor1 and TnpB structures highlights divergent evolutionary paths, advancing our understanding of RNA-guided endonucleases. Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily.,Schargel RD, Qayyum MZ, Tanwar AS, Kalathur RC, Kellogg EH Nat Struct Mol Biol. 2024 Oct 1. doi: 10.1038/s41594-024-01394-4. PMID:39354233 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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