8vae | pdb_00008vae

Cryogenic electron microscopy structure of human serum albumin in complex with salicylic acid

spinqualitylabelsall models 8vae, resolution 3.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8vae is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.7Å Ligands: SAL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Human serum albumin (HSA) is the most prevalent plasma protein in the human body, accounting for 60 % of the total plasma protein. HSA plays a major pharmacokinetic function, serving as a facilitator in the distribution of endobiotics and xenobiotics within the organism. In this paper we report the cryoEM structures of HSA in the apo form and in complex with two ligands (salicylic acid and teniposide) at a resolution of 3.5, 3.7 and 3.4 A, respectively. We expand upon previously published work and further demonstrate that sub-4 A maps of approximately 60 kDa proteins can be routinely obtained using a 200 kV microscope, employing standard workflows. Most importantly, these maps allowed for the identification of small molecule ligands, emphasizing the practical applicability of this methodology and providing a starting point for subsequent computational modeling and in silico optimization. The CryoEM structure of human serum albumin in complex with ligands.,Catalano C, Lucier KW, To D, Senko S, Tran NL, Farwell AC, Silva SM, Dip PV, Poweleit N, Scapin G J Struct Biol. 2024 Sep;216(3):108105. doi: 10.1016/j.jsb.2024.108105. Epub 2024 , Jun 8. PMID:38852682 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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