Structural highlights
Function
TMP2L_NEMVE Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). Functions as a ligand-gated ion channel (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:25620041, PubMed:27333281, PubMed:28775320, PubMed:29745897). May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species (PubMed:25620041, PubMed:27333281).[1] [2] [3] [4]
References
- ↑ Kühn FJ, Kühn C, Lückhoff A. Functional characterisation of a TRPM2 orthologue from the sea anemone Nematostella vectensis in human cells. Sci Rep. 2015 Jan 26;5:8032. PMID:25620041 doi:10.1038/srep08032
- ↑ Kühn FJ, Kühn C, Winking M, Hoffmann DC, Lückhoff A. ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain. PLoS One. 2016 Jun 22;11(6):e0158060. PMID:27333281 doi:10.1371/journal.pone.0158060
- ↑ Kühn FJP, Mathis W, Cornelia K, Hoffmann DC, Lückhoff A. Modulation of activation and inactivation by Ca(2+) and 2-APB in the pore of an archetypal TRPM channel from Nematostella vectensis. Sci Rep. 2017 Aug 3;7(1):7245. PMID:28775320 doi:10.1038/s41598-017-07652-4
- ↑ Zhang Z, Toth B, Szollosi A, Chen J, Csanady L. Structure of a TRPM2 channel in complex with Ca(2+) explains unique gating regulation. Elife. 2018 May 10;7. pii: 36409. doi: 10.7554/eLife.36409. PMID:29745897 doi:https://dx.doi.org/10.7554/eLife.36409
