6gh8 | pdb_00006gh8

Crystal structure of GP1 domain of Lujo virus in complex with the first CUB domain of neuropilin-2

spinqualitylabelsall models 6gh8, resolution 2.44Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6gh8 is a 4 chain structure with sequence from Homo sapiens and Mammarenavirus lujoense. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.44Å Ligands: CA, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C5ILC1_9VIRU Publication Abstract from PubMed Lujo virus (LUJV) has emerged as a highly fatal human pathogen. Despite its membership among the Arenaviridae, LUJV does not classify with the known Old and New World groups of that viral family. Likewise, LUJV was recently found to use neuropilin-2 (NRP2) as a cellular receptor instead of the canonical receptors used by Old World and New World arenaviruses. The emergence of a deadly pathogen into human populations using an unprecedented entry route raises many questions regarding the mechanism of cell recognition. To provide the basis for combating LUJV in particular, and to increase our general understanding of the molecular changes that accompany an evolutionary switch to a new receptor for arenaviruses, we used X-ray crystallography to reveal how the GP1 receptor-binding domain of LUJV (LUJVGP1) recognizes NRP2. Structural data show that LUJVGP1 is more similar to Old World than to New World arenaviruses. Structural analysis supported by experimental validation further suggests that NRP2 recognition is metal-ion dependent and that the complete NRP2 binding site is formed in the context of the trimeric spike. Taken together, our data provide the mechanism for the cell attachment step of LUJV and present indispensable information for combating this phatogen. Structural basis for receptor recognition by Lujo virus.,Cohen-Dvashi H, Kilimnik I, Diskin R Nat Microbiol. 2018 Aug 27. pii: 10.1038/s41564-018-0224-5. doi:, 10.1038/s41564-018-0224-5. PMID:30150732 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Neuropilin

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