1xuo | pdb_00001xuo
|
X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution
Overview
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1, inhibitors. The synthesis, structure, and biological evaluation of these, 1,4-diazepine-2,5-diones and related derivatives are described.
About this Structure
1XUO is a Single protein structure of sequence from Homo sapiens with MG and LA1 as ligands. Full crystallographic information is available from OCA.
Reference
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945
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