1xur | pdb_00001xur

File:1xur.gif

spinqualitylabelsall models 1xur, resolution 1.850Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor

Overview

The paradigm for matrix metalloprotease inhibition combines active site, tailoring and catalytic zinc ligation. But, selectivity has been, difficult. Now, Engel et al. present novel compounds, completely selective, for MMP-13, with a unique binding mode.

About this Structure

1XUR is a Single protein structure of sequence from Homo sapiens with ZN, CA and PB5 as ligands. Full crystallographic information is available from OCA.

Reference

Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640

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