4art | pdb_00004art

STRUCTURE OF THE ORF273 PROTEIN FROM THE ACIDIANUS TWO-TAILED VIRUS

spinqualitylabelsall models 4art, resolution 2.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4art is a 2 chain structure with sequence from Acidianus two-tailed virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.15Å Ligands: GOL, SO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Acidianus two-tailed virus (ATV) infects crenarchaea of the genus Acidianus living in terrestrial thermal springs at extremely high temperatures and low pH. ATV is a member of the Bicaudaviridae virus family and undergoes extra-cellular development of two tails, a process that is unique in the viral world. To understand this intriguing phenomenon, we have undertaken structural studies of ATV virion proteins and here we present the crystal structure of one of these proteins, ATV[Formula: see text]. ATV[Formula: see text] forms tetramers in solution and a molecular envelope is provided for the tetramer, computed from small-angle X-ray scattering (SAXS) data. The crystal structure has properties typical of hyperthermostable proteins, including a relatively high number of salt bridges. However, the protein also exhibits flexible loops and surface pockets. Remarkably, ATV[Formula: see text] displays a new [Formula: see text] protein fold, consistent with the absence of homologues of this protein in public sequence databases. Crystal Structure of ATV(ORF273), a New Fold for a Thermo- and Acido-Stable Protein from the Acidianus Two-Tailed Virus.,Felisberto-Rodrigues C, Blangy S, Goulet A, Vestergaard G, Cambillau C, Garrett RA, Ortiz-Lombardia M PLoS One. 2012;7(10):e45847. doi: 10.1371/journal.pone.0045847. Epub 2012 Oct 8. PMID:23056221 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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