2n7t | pdb_00002n7t

NMR structure of Peptide PG-992 in DPC micelles

spinqualitylabelsall models 2n7t Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2n7t is a 1 chain structure with sequence from Synthetic construct. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 10 models Ligands: 4J2, ACE, NH2, NLE Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated patho-physiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective lig-ands. Here, we report the design, synthesis, biological activity, conformational analysis and docking with receptors of two potent and selective agonists at the human MC3 receptor. Discovery of Novel Potent and Selective Agonists at the Melanocortin3 Receptor.,Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P J Med Chem. 2015 Nov 24. PMID:26599352 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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