8zf0 | pdb_00008zf0

pRib-ADP bound OsEDS1-PAD4-ADR1 complex

spinqualitylabelsall models 8zf0, resolution 2.96Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8zf0 is a 3 chain structure with sequence from Oryza sativa Japonica Group. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.96Å Ligands: A1D8A Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0E0JBT6_ORYNI Publication Abstract from PubMed The Ca(2+) sensor, ROD1, is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR (TIR-only protein), OsEDS1 (Enhanced Disease Susceptibility 1), OsPAD4 (Phytoalexin Deficient 4), and OsADR1 (Activated Disease Resistance 1) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the production of second messengers 2'-(5-phosphoribosyl)-5'-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity while mutation of ROD1 leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice. A canonical protein complex controls immune homeostasis and multipathogen resistance.,Wu Y, Xu W, Zhao G, Lei Z, Li K, Liu J, Huang S, Wang J, Zhong X, Yin X, Wang Y, Zhang H, He Y, Ye Z, Meng Y, Chang X, Lin H, Wang X, Gao Y, Chai J, Parker JE, Deng Y, Zhang Y, Gao M, He Z Science. 2024 Nov 7:eadr2138. doi: 10.1126/science.adr2138. PMID:39509474 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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