8y6n | pdb_00008y6n

The structure of Oryza sativa HKT1;5 salt tolerant variant

spinqualitylabelsall models 8y6n, resolution 3.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8y6n is a 2 chain structure with sequence from Escherichia coli and Oryza sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function C562_ECOLX Electron-transport protein of unknown function.M1G2X2_ORYSA Publication Abstract from PubMed The high-affinity potassium transporters (HKTs), selectively permeable to either Na(+) alone or Na(+)/K(+), play pivotal roles in maintaining plant Na(+)/K(+) homeostasis. Although their involvement in salt tolerance is widely reported, the molecular underpinnings of Oryza sativa HKTs remain elusive. In this study, we elucidate the structures of OsHKT1;1 and OsHKT2;1, representing two distinct classes of rice HKTs. The dimeric assembled OsHKTs can be structurally divided into four domains. At the dimer interface, a half-helix or a loop in the third domain is coordinated by the C-terminal region of the opposite subunit. Additionally, we present the structures of OsHKT1;5 salt-tolerant and salt-sensitive variants, a key quantitative trait locus associated with salt tolerance. The salt-tolerant variant of OsHKT1;5 exhibits enhanced Na(+) transport capability and displays a more flexible conformation. These findings shed light on the molecular basis of rice HKTs and provide insights into their role in salt tolerance. Structural insights into the Oryza sativa cation transporters HKTs in salt tolerance.,Gao R, Jia Y, Xu X, Fu P, Zhou J, Yang G J Integr Plant Biol. 2024 Apr;66(4):700-708. doi: 10.1111/jipb.13632. Epub 2024 , Feb 26. PMID:38409933 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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