9bch | pdb_00009bch

Solution structure of the hemoglobin receptor HbpA from Corynebacterium diphtheriae

spinqualitylabelsall models 9bch Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9bch is a 1 chain structure with sequence from Corynebacterium diphtheriae NCTC 13129. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR, 20 models Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q6NEE5_CORDI Publication Abstract from PubMed To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. Corynebacterium diphtheriae causes the life-threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface-displayed receptor HbpA. Here, we show using X-ray crystallography, NMR, and in situ binding measurements that C. diphtheriae selectively captures iron-loaded hemoglobin by partially ensconcing the heme molecules of its alpha subunits. Quantitative growth and heme release measurements are compatible with C. diphtheriae acquiring heme passively released from hemoglobin's beta subunits. We propose a model in which HbpA and heme-binding receptors collectively function on the C. diphtheriae surface to capture hemoglobin and its spontaneously released heme. Acquisition mechanisms that exploit the propensity of hemoglobin's beta subunit to release heme likely represent a common strategy used by bacterial pathogens to obtain iron during infections. Molecular basis of hemoglobin binding and heme removal in Corynebacterium diphtheriae.,Mahoney BJ, Lyman LR, Ford J, Soule J, Cheung NA, Goring AK, Ellis-Guardiola K, Collazo MJ, Cascio D, Ton-That H, Schmitt MP, Clubb RT Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2411833122. doi: , 10.1073/pnas.2411833122. Epub 2024 Dec 31. PMID:39739808 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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