8ytu | pdb_00008ytu

Mipa-PETase from Micromonospora pattaloongensis

spinqualitylabelsall models 8ytu, resolution 1.34Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ytu is a 3 chain structure with sequence from Micromonospora pattaloongensis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.34Å Ligands: EDO, GOL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1H3QT72_9ACTN Publication Abstract from PubMed Enzymes capable of breaking down polymers have been identified from natural sources and developed for industrial use in plastic recycling. However, there are many potential starting points for enzyme optimization that remain unexplored. We generated a landscape of 170 lineages of 1894 polyethylene terephthalate depolymerase (PETase) candidates and performed profiling using sampling approaches with features associated with PET-degrading capabilities. We identified three promising yet unexplored PETase lineages and two potent PETases, Mipa-P and Kubu-P. An engineered variant of Kubu-P outperformed benchmarks in terms of PET depolymerization in harsh environments, such as those with high substrate load and ethylene glycol as the solvent. Landscape profiling of PET depolymerases using a natural sequence cluster framework.,Seo H, Hong H, Park J, Lee SH, Ki D, Ryu A, Sagong HY, Kim KJ Science. 2025 Jan 3;387(6729):eadp5637. doi: 10.1126/science.adp5637. Epub 2025 , Jan 3. PMID:39745946 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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