8qep | pdb_00008qep

RNA polymerase II bound to Alu RNA right arm

spinqualitylabelsall models 8qep, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8qep is a 10 chain structure with sequence from Sus scrofa domesticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.5Å Ligands: ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A8D1DPV6_PIG DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[RuleBase:RU004279] Publication Abstract from PubMed Transcription by RNA polymerase II (Pol II) can be repressed by noncoding RNA, including the human RNA Alu. However, the mechanism by which endogenous RNAs repress transcription remains unclear. Here we present cryogenic-electron microscopy structures of Pol II bound to Alu RNA, which reveal that Alu RNA mimics how DNA and RNA bind to Pol II during transcription elongation. Further, we show how distinct domains of the general transcription factor TFIIF control repressive activity. Together, we reveal how a noncoding RNA can regulate mammalian gene expression. Mechanism of mammalian transcriptional repression by noncoding RNA.,Tluckova K, Kaczmarek B, Salmazo A, Bernecky C Nat Struct Mol Biol. 2025 Jan 6. doi: 10.1038/s41594-024-01448-7. PMID:39762629 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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