Complement factor 3D structures

3D structures of complement factor

Updated on 03-February-2025

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• Complement factor B
  • 2ok5 – hCFB residues 26-764 - human
    
  • 1dle – hCFB serine protease domain residues 470-764
    
  • 1q0p – hCFB residues 254-476 (mutant)
    
  • 1rrk – hCFB BB fragment residues 243-764 (mutant)
    
• Complement factor B complexes
  • 1rs0 – hCFB BB fragment (mutant) + DIP
    
  • 1rtk – hCFB BB fragment (mutant) + guanidinobenzoate
    
  • 6rur – hCFB + complement C3 α+β chains
    
  • 2xwj – hCFB (mutant) + complement C3 α+β chains
    
  • 8enu – hCFB + complement C3B a+b chains + lufaxin – Cryo EM
    
  • 8uin – hCFB + complement C3B a+b chains + albicin – Cryo EM
    
  • 8eok – hCFB + complement C3B a+b chains + lufaxin + factor Xa – Cryo EM
    
  • 3hrz, 3hs0 – hCFB (mutant) + cobra venom factor
    
  • 7jtn, 7jtq – hCFB + DNA
    
  • 6qsw, 6qsx, 6rav, 6t8v, 6t8w, 6tbu – hCFB protease domain + inhibitor
    
• Complement factor D
  • 1dsu, 1hfd – hCFD
    
  • 1dst, 2xw9, 2xwa, 4cbn, 4cbo – hCFD (mutant)
    
  • 1fdp – hCFD proenzyme
    
• Complement factor D complexes
  • 1bio, 1dfp, 1dic, 5fbe, 5fbi, 5fck, 5fcr, 5mt0, 5mt4, 5nar, 5nat, 5naw, 5nb6, 5nb7, 5nba, 5tca, 5tcc,6qmr, 6qmt, 6fut, 6fuj, 6fui, 6fuh, 6fug, 6ftz, 6fty, 8d95, 8dea, 8dg6 – hCFD + inhibitor
    
  • 4d9r, 6vmj, 6vmk – hCFD + antibody
    
• Complement factor H
  • 1haq, 3gau, 3gav, 3gaw – hCFH - NMR
    
  • 2rlp – hCFH 1-2 sushi domains - NMR
    
  • 2rlq – hCFH 2-3 sushi domains - NMR
    
  • 2qfg – hCFH 1-5 sushi domains
    
  • 2yby – mCFH 6-8 sushi domains (mutant) - mouse
    
  • 2ic4 – hCFH 6-8 sushi domains (mutant)
    
  • 2jgw – hCFH 7 sushi domain – NMR
    
  • 2jgx – hCFH 7 sushi domain (mutant)
    
  • 4b2r – hCFH 10-11 sushi domains - NMR
    
  • 4b2s – hCFH 11-12 sushi domains - NMR
    
  • 2kms – hCFH 12-13 sushi domains – NMR
    
  • 1hfi – hCFH 15 sushi domain – NMR
    
  • 1hfh – hCFH 15-16 sushi domains – NMR
    
  • 2qfh – hCFH 16-20 sushi domains - NMR
    
  • 3sw0 – hCFH 18-20 sushi domains
    
  • 2bzm – hCFH 19-20 sushi domains – NMR
    
  • 3kzj – hCFH 19-20 sushi domains (mutant) – NMR
    
  • 2g7i – hCFH 19-20 sushi domains
    
  • 3kxv, 3r62 – hCFH 19-20 sushi domains (mutant)
    
• Complement factor H complexes
  • 2wii – hCFH 1-4 sushi domains + complement C3
    
  • 2w80, 2w81, 4ayd, 4aye, 4ayi, 4aym – hCFH 6-7 sushi domains + factor H binding protein
    
  • 2uwn, 2v8e – hCFH 6-8 sushi domains + sucrose octasulfate
    
  • 4k12 – hCFH 9 sushi domain + choline binding protein A
    
  • 3oxu, 4ont, 4zh1 – hCFH 19-20 sushi domains + complement C3
    
  • 2xqw – hCFH 19-20 sushi domains (mutant) + complement C3
    
  • 4j38 – hCFH 19-20 sushi domains (mutant) + outer surface protein E
    
  • 4k12 – hCFH 9 sushi domain + choline binding protein A
    
  • 5nbq – hCFH + complement C3 α chain + outer surface protein
    
  • 5o32 – hCFH + hCFI + complement C3 α+β chains
    
  • 5o35 – hCFH + complement C3 α chain
    
  • 7wki – hCFH + nanobody
    
  • 9f7i – hCFH + CRASP-2
    
  • 7zjm – hCFH + CSPZ
    
  • 6zh1 – hCFH + CFH-binding protein
    
  • 6xz6 – CFH + factor H receptor - bovine
    
• Complement factor I
  • 2xrc – hCFI
    
• Complement factor P or properdin
  • 6rus, 6rv6, 6s08, 6s0a, 6sej – hCFP
    
  • 6s0b – hCFP + complement C3
    
  • 6rur – hCFP + complement C3 + CFB + protein inhibitor
    
  • 6ruv – hCFP + complement C3 + CFB + nanobody + protein inhibitor
    
  • 7noz – hCFP + complement C3 + CFB + nanobody + properdin
    

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Michal Harel, Joel L. Sussman