9eke | pdb_00009eke

Structure of a C1r Zymogen Fragment Bound to SALO, Y51F Mutant

spinqualitylabelsall models 9eke, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 9eke is a 4 chain structure with sequence from Homo sapiens and Lutzomyia longipalpis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.1Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function SALO_LUTLO Salivary protein that inhibits the classical pathway of complement system activation in the host while having no inhibitory effect on the alternative or lectin pathways (PubMed:26758086, PubMed:28278244). Prevent cleavage of host C4 and consequently impairs the activation of factors downstream of C4b in the complement cascade (PubMed:26758086).

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