8jiw | pdb_00008jiw

Atomic structure of wheat ribosome reveals unique features of the plant ribosomes

spinqualitylabelsall models 8jiw, resolution 2.88Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8jiw is a 10 chain structure with sequence from Triticum aestivum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.88Å Ligands: A2M, K, MA6, MG, OMC, OMG, OMU, PSU, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Plants being sessile organisms exhibit unique features in ribosomes, which might aid in rapid gene expression and regulation in response to varying environmental conditions. Here, we present high-resolution structures of the 60S and 80S ribosomes from wheat, a monocot staple crop plant (Triticum aestivum). While plant ribosomes have unique plant-specific rRNA modification (Cm1847) in the peptide exit tunnel (PET), the zinc-finger motif in eL34 is absent, and uL4 is extended, making an exclusive interaction network. We note differences in the eL15-helix 11 (25S) interaction, eL6-ES7 assembly, and certain rRNA chemical modifications between monocot and dicot ribosomes. In eukaryotes, we observe highly conserved rRNA modification (Gm75) in 5.8S rRNA and a flipped base (G1506) in PET. These features are likely involved in sensing or stabilizing nascent chain. Finally, we discuss the importance of the universal conservation of three consecutive rRNA modifications in all ribosomes for their interaction with A-site aminoacyl-tRNA. Cryo-EM structure of wheat ribosome reveals unique features of the plant ribosomes.,Mishra RK, Sharma P, Khaja FT, Uday AB, Hussain T Structure. 2024 May 2;32(5):562-574.e3. doi: 10.1016/j.str.2024.02.006. Epub 2024 , Mar 7. PMID:38458197 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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