Cyclic GMP-AMP synthase 3D structures

3D structures of cyclic GMP-AMP synthase

Updated on 12-February-2025

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• cyclic GMP-AMP synthase
  • 4km5, 4mkp, 4lev, 4lew, 4o68, 4o69 – hCGAS Catalytic domain 157-522 – human
    
  • 4jlx – pCGAS Catalytic domain – pig
    
  • 4k8v, 7kxs – mCGAS Catalytic domain – mouse
    
  • 7lz3 – CGAS catalytic domain – synthetic
    
  • 4txy, 4xj1 – VcCGAS – Vibrio cholerae
    
  • 4u0l, 4u0n, 5go3 – VcCGAS (mutant)
    
  • 7d48 – CGAS – Enterobacter cloacae
    
• Cyclic GMP-AMP synthase complex
  • 4o67 - hCGAS Catalytic domain + cyclic GMP-AMP
    
  • 5vdo, 5vdt, 5vdp, 6mjx - hCGAS Catalytic domain + CGAMP
    
  • 6nao - hCGAS Catalytic domain + CGAS
    
  • 5vdq - hCGAS Catalytic domain + GPAP
    
  • 5vdr - hCGAS Catalytic domain + CDIMP
    
  • 5vds - hCGAS Catalytic domain + CDUMP
    
  • 6edc - hCGAS catalytic domain + DNA
    
  • 6ct9 - hCGAS catalytic domain (mutant) + DNA
    
  • 6cta - hCGAS Catalytic domain (mutant) + DNA + ATP
    
  • 6nao, 5v8o, 5vdu, 5vdv, 5vdw, 6nfo, 6lrc, 6lre, 6lri, 6lrj, 6lrk, 6lrl, 6mju, 6mjw, 6nfg, 6nfo - hCGAS Catalytic domain + inhibitor
    
  • 6o47 - hCGAS Catalytic domain (mutant) + inhibitor
    
  • 7c0m – hCGAS in nucleosome – Cryo EM
    
  • 4kb6 – pCGAS Catalytic domain + DNA + ATP + GTP
    
  • 4jlz – pCGAS Catalytic domain + UTP
    
  • 4k96, 4ley, 4lez, 4o6a, 5n6i, 5xzb, 5xze, 5xzg – mCGAS Catalytic domain + DNA
    
  • 4k97 – mCGAS Catalytic domain + DNA + ATP
    
  • 4k98, 4k99, 4k9a, 4k9b – mCGAS Catalytic domain + DNA + polynucleotide
    
  • 7bum, 7buq – mCGAS Catalytic domain + AMP + GMP
    
  • 7buj – mCGAS Catalytic domain + GTP + GMP
    
  • 7a08, 7ccq, 7ccr, 7jo9, 7joa – mCGAS in human nucleosome – Cryo EM
    
  • 6y5d, 6y5e – mCGAS (mutant) in human nucleosome – Cryo EM
    
  • 6x59, 6x5a, 6xjd – mCGAS catalytic domain in human nucleosome – Cryo EM
    
  • 4txz, 4xj3, 4xj5 – VcCGAS + GTP
    
  • 4xj4 – VcCGAS + ATP
    
  • 4ty0 – VcCGAS + PPPAPG
    
  • 4u03 – VcCGAS + GTP + 5MTHFGlu2
    
  • 4u0m – VcCGAS (mutant) + GTP + ATP + 5MTHFGlu2
    

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Michal Harel, Jaime Prilusky