8qe9 | pdb_00008qe9

Complex between the 80a-Sak SSAP and the SaPI2 Stl master regulator

spinqualitylabelsall models 8qe9, resolution 3.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8qe9 is a 64 chain structure with sequence from Staphylococcus aureus and Staphylococcus phage 80alpha. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.9Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0FIL5_STAAU Publication Abstract from PubMed Bacteria often carry multiple genes encoding anti-phage defense systems, clustered in defense islands and phage satellites. Various unrelated anti-phage defense systems target phage-encoded homologous recombinases (HRs) through unclear mechanisms. Here, we show that the phage satellite SaPI2, which does not encode orthodox anti-phage defense systems, provides antiviral immunity mediated by Stl2, the SaPI2-encoded transcriptional repressor. Stl2 targets and inhibits phage-encoded HRs, including Sak and Sak4, two HRs from the Rad52-like and Rad51-like superfamilies. Remarkably, apo Stl2 forms a collar of dimers oligomerizing as closed rings and as filaments, mimicking the quaternary structure of its targets. Stl2 decorates both Sak rings and Sak4 filaments. The oligomerization of Stl2 as a collar of dimers is necessary for its inhibitory activity both in vitro and in vivo. Our results shed light on the mechanisms underlying antiviral immunity against phages carrying divergent HRs. Phage parasites targeting phage homologous recombinases provide antiviral immunity.,Debiasi-Anders G, Qiao C, Salim A, Li N, Mir-Sanchis I Nat Commun. 2025 Feb 22;16(1):1889. doi: 10.1038/s41467-025-57156-3. PMID:39987160 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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