8y8r | pdb_00008y8r

Cryo-EM structure of AQP3 Y212T in DDM micelle

spinqualitylabelsall models 8y8r, resolution 3.39Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8y8r is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.39Å Ligands: LMT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function AQP3_RAT Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed:7517548, PubMed:7526388). Could also be permeable to urea (PubMed:7517548, PubMed:7526388). Also participates in cell permeability to H2O2 and H2O2-mediated signaling (By similarity). In skin, transports glycerol to the epidermis and stratum corneum, where it maintains hydration, elasticity, and supports lipid biosynthesis for barrier repair. In kidney, contributes to the reabsorption of water, helping the body maintain proper fluid balance (By similarity).[UniProtKB:Q8R2N1][UniProtKB:Q92482]

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