1ywi | pdb_00001ywi
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Structure of the FBP11WW1 domain complexed to the peptide APPTPPPLPP
Overview
WW domains are small protein-protein interaction modules that recognize, proline-rich stretches in proteins. The class II tandem WW domains of the, formin binding protein 11 (FBP11) recognize specifically proteins, containing PPLPp motifs as present in the formins that are involved in, limb and kidney development, and in the methyl-CpG-binding protein 2, (MeCP2), associated with the Rett syndrome. The interaction involves the, specific recognition of a leucine side-chain. Here, we report on the novel, structure of the complex formed by the FPB11WW1 domain and the formin, fragment APPTPPPLPP revealing the specificity determinants of class II WW, domains.
About this Structure
1YWI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for APPTPPPLPP peptide recognition by the FBP11WW1 domain., Pires JR, Parthier C, Aido-Machado R, Wiedemann U, Otte L, Bohm G, Rudolph R, Oschkinat H, J Mol Biol. 2005 Apr 29;348(2):399-408. PMID:15811376
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