2bf9 | pdb_00002bf9

Anisotropic refinement of avian (turkey) pancreatic polypeptide at 0. 99 Angstroms resolution.

spinqualitylabelsall models 2bf9, resolution 0.99Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 2bf9 is a 1 chain structure with sequence from Meleagris gallopavo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 0.99Å Ligands: TYC, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PAHO_MELGA Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed A pancreatic polypeptide with some hormonal properties has been purified from chicken and turkey pancreas using acid-ethanol extraction, gel filtration and anion-exchange chromatography. The material has been crystallised. The crystals are monoclinic with space group C2. Preliminary isomorphous replacement experiments have so far provided a single-site derivative with Hg(NO3)2. A low-resolution electron density map phased with this derivative using anomalous scattering considered together with Patterson function calculations suggest that the molecules are partly helical and are arranged as a compact dimer about the crystallographic two-fold axis. The structure and association of these molecules are compared with those of insulin and glucagon, pancreatic protein and polypeptide hormones respectively, which have been studied in great detail. Purification, crystallisation and preliminary X-ray studies on avian pancreatic polypeptide.,Wood SP, Pitts JE, Blundell TL, Tickle IJ, Jenkins JA Eur J Biochem. 1977 Aug 15;78(1):119-26. PMID:000913391 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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