8ozo | pdb_00008ozo

Populus tremula stable protein 1 with N-terminal binding peptide extension

spinqualitylabelsall models 8ozo, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 8ozo is a 24 chain structure with sequence from Populus tremula. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9AR79_POPTN Publication Abstract from PubMed Enzymes have gained their unique efficiency and catalytic activity through billions of years of evolution, perfecting their active site to a desired reaction. Inspired by nature, a novel enzyme-mimicking platform is designed based on stable protein 1 (SP1) to create a nano-compartment that mimics peroxidase activity. The biohybrid reveals enhanced activity over the hemin cofactor alone and improved stability in organic solvents in comparison to native peroxidase. Furthermore, the utilization of the obtained biohybrid in an optical glucose biosensing platform is shown. The biohybrid crystallographic structure is solved, indicating that the SP1 structure is not affected by the hemin coordination. This work opens the path for developing new cofactor binding centers in engineered protein scaffolds for various artificial catalytic processes. A Bioengineered Stable Protein 1-Hemin Complex with Enhanced Peroxidase-Like Catalytic Properties.,Zeibaq Y, Bachar O, Sklyar J, Adir N, Yehezkeli O Small Sci. 2024 Mar 19;4(6):2400025. doi: 10.1002/smsc.202400025. eCollection , 2024 Jun. PMID:40212758 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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