IRI3

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The formation of ice (cyan spheres) is inhibited by the placement of interacting water molecules
A line of asparagines in the center of the roll gives structural stability to the beta-sheet roll motif


Lolium perenne (Perennial ryegrass) Antifreeze/Ice-binding protein IRI3

Structural highlights

Ice-Binding Site

References

Middleton AJ, Marshall CB, Faucher F, Bar-Dolev M, Braslavsky I, Campbell RL, Walker VK, Davies PL. Antifreeze protein from freeze-tolerant grass has a beta-roll fold with an irregularly structured ice-binding site. J Mol Biol. 2012 Mar 9;416(5):713-24. doi: 10.1016/j.jmb.2012.01.032. Epub 2012 Jan 28. PMID: 22306740.

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