6d7w | pdb_00006d7w

Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution

Loading... Status: waiting for Mol* initialization Structural highlights 6d7w is a 4 chain structure with sequence from Aspergillus fischeri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.8Å Ligands: CA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function MCU_NEOFI Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix (PubMed:29995855). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways (PubMed:29995855). Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit (PubMed:29995855). See Also Mitochondrial calcium uniporter

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