Farnesyl diphosphate synthase 3D structures

3D structures of farnesyl diphosphate synthase

Updated on 08-June-2025

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• Farnesyl diphosphate synthase
  • 1zw5, 2f7m, 4xqr, 4xqs, 4xqt – hFPS – human
    
  • 1fps– cFPS – chicken
    
  • 1ubv – cFPS (mutant)
    
  • 8wd5 – FPS – silkworm
    
  • 5hxn – z,z-FPS – tomato
    
  • 5hxo – z,z-FPS (mutant)
    
  • 1rtr– FPS – Staphylococcus aureus
    
  • 1yhk, 5qqc, 6r04, 3iba, 3icz, 3icm, 3icn, 1yhl, 6se2, 6sfa – TcFPPS – Trypanosoma cruzi
    
  • 6vjc, 6w71, 4k10, 4jzb, 4jzx– LmFPPS – Leishmania major
    
  • 3lvs, 3m0g – FPS – Rhodobacter capsulatus
    
  • 3m9u – LbFPS – Lactobacillus brevis
    
  • 5ayp – FPS – Geobacillus stearothermophilus
    
  • 6ww1 – LmFPS (mutant) – Leishmania major
    
  • 4ryp – TbFPS –Trypanosoma brucei
    
  • 3ts7 – FPS – Methylococcus capsulatus
    
  • 8f8f – MtFPS – Mycobacterium tuberculosis
    
• FPS binary complexes
  • 1yq7, 1yv5, 2f89, 2f8c, 2f92, 2f94, 2f9k, 2rah, 2opn, 2vf6, 3b7l, 2opm, 3n1v, 3n1w, 3n3l, 3n45, 3n46, 3n49, 3n5j, 3n6k, 3n5h, 4dem, 4ga3, 4jvj, 4pvx, 4pvy, 4rxa, 5dgn, 5diq, 5djp, 5djr, 5djv, 5juz, 5jv0, 5jv1, 5jv2, 5ksx, 5ygi, 6n7y, 6n7z, 6n82, 6n83, 6oag, 6oah - hFPS + inhibitor
    
  • 2qis, 3cp6, 3rye, 3s4j, 4n9u - hFPS (mutant) + inhibitor
    
  • 4kfa, 4kpj, 4kq5 - hFPS (mutant) + osteoporosis drug
    
  • 4lpg, 4lph, 4n1z, 4p0x - hFPS + drug
    
  • 4nfi, 4nfj, 4nfk, 4qxs, 4qpf, 5cg5 - hFPS + bisphosphonate
    
  • 4ng6, 4nke, 4nkf, 4nua, 4ogu, 4q23 - hFPS (mutant) + bisphosphonate
    
  • 5dgm, 5dgs - hFPS + monophosphonate
    
  • 5ja0 - hFPS + FPP
    
  • 1ubw, 1ubx - cFPS (mutant) + GDP
    
  • 1uby - cFPS (mutant) + dimethylallyl PP
    
  • 6b07, 6b02, 6b04, 6b06 – FPS + inhibitor – spruce budworm moth
    
  • 5hxp – z,z-FPS (mutant) + IPP
    
  • 5hxq – z,z-FPS (mutant) + DMSPP
    
  • 2i19, 2ewg, 2ogd, 2p1c, 3dyg, 3dyh, 3efq, 3egt, 4rxe, 5ael, 5afx - TbFPS + inhibitor
    
  • 4rxd – TbFBS + risedronate
    
  • 2for– FPS + IPP – Shigella flexneri
    
  • 4jzb, 4jzx, 4k10 – Leshmaniasis major FPS + inhibitor
    
  • 3id0, 3iba, 3ick, 3icm, 3icn, 3icz, 4rxc, 5ahu, 5qpd, 6sdn, 6sdo, 6sdp, 6sdq, 6sf8, 6sf9, 6shv, 6si5 – TcFPS + inhibitor
    
  • 6t7n – TcFPS + IPP
    
  • 5qpe, 5qpk, 5qpo, 5qq3, 5qq8 – TcFPS + imidazole inhibitor
    
  • 5qpg, 5qpn, 6r08 – TcFPS + indole inhibitor
    
  • 5qpf, 5qq1, 6r09, 6r0a, 6r0b – TcFPS + piperazine inhibitor
    
  • 6r06 – TcFPS + piperidine inhibitor
    
  • 5qph, 5qq0 – TcFPS + morpholine inhibitor
    
  • 5qpi, 5qpw, 5qpy, 5qq5, 5qqa – TcFPS + pyrazole inhibitor
    
  • 5qps – TcFPS + oxazole inhibitor
    
  • 5qpj, 5qpu, 5qq9 – TcFPS + acetamide inhibitor
    
  • 5qpq – TcFPS + ethanamide inhibitor
    
  • 5qpv – TcFPS + caboxamide inhibitor
    
  • 5qpl, 5qpm, 5qpp, 5qpr, 5qpz, 5qq4 – TcFPS + urea inhibitor
    
  • 5qpt – TcFPS + thiazine inhibitor
    
  • 5qq2, 6r07 – TcFPS + thiophene inhibitor
    
  • 5qpx – TcFPS + quinoline inhibitor
    
  • 5qq6, 5qq7 – TcFPS + pyrrolidine inhibitor
    
  • 6r05 – TcFPS + pyridine inhibitor
    
  • 5qqb – TcFPS + benzodiazo inhibitor
    
  • 3pde – LbFPS + IPP
    
  • 8f8k – MtFPS + IPP
    
  • 8f8l – MtFPS + DMAP
    
  • 6vjc – LmFPS (mutant) + inhibitor
    
  • 4llt - RdFPS + IPP – Roseobacter denitrificans
    
  • 7my6 - FPS + IPP – Synechococcus elongatus<br />
• FPS ternary complexes
  • 2f8z, 4h5e - hFPS + IPP + inhibitor
    
  • 4kpd, 4kqs, 4kqu - hFPS (mutant) + IPP + osteoporosis drug
    
  • 4p0v, 4p0w - hFPS + 2 drugs
    
  • 4h5c, 4h3c, 4h5d, 4lfv - hFPS + phosphate + inhibitor
    
  • 5cg6 - hFPS + IPP + bisphosphonate
    
  • 4l2x - hFPS + PP + inhibitor
    
  • 5hxt – z,z-FPS (mutant) + DMSPP + IPP
    
  • 1rqi – EcFPS + IPP + dimethylallyl S-thioloPP – Escherichia coli
    
  • 1rqj - EcFPS + IPP + inhibitor
    
  • 1yhl – TcFPS + dimethylallyl PP + inhibitor
    
  • 1yhm, 3iba, 3ick, 3icm, 3icn, 3icz, 4dwb, 4dwg, 4dxj, 4dzw, 4e1e - TcFPS + IPP + inhibitor
    
  • 3ez3 - PvFPS + IPP + inhibitor – Plasmodium vivax
    
  • 3dyf - TbFPS + IPP + inhibitor
    
  • 4lls - RdFPS + IPP + geranyl derivative
    

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